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Updated: Aug 20, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
[Protective effect of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury in rats]
Zhi-peng Wang1, Li Liu, Qi-bing Mei
1Department of Pharmacology, the Fourth Military Medical University, Xian Shaanxi 710032, China.
Objective:
To evaluate protective effects of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury (TBI) in rats.
Method:
The polysaccharides (RTP) were extracted from Tanguficum Maxim. 120 rats were divided into 15 groups, with 8 rats in each group. RTP at 100, 200 and 400 mg x kg(-1) were administrated orally once a day for five days, and model of brain injury was made by dropping weight method.
Result:
RTP reduced water content and malondialdehyde (MDA) levels, and increased total SOD activity and Na+-K+ ATPase activity after injuried.
Conclusion:
The polysaccharides may be one of the effective comptents in Rheum tanguticum, showing significant neuroprotective effects.

