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Cytotoxic steroidal saponins from Polygonatum zanlanscianense
Jian-Ming Jin1, Ying-Jun Zhang, Hai-Zhou Li
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Abstract:
Four new steroidal saponins, polygonatosides A-D (1-4), were isolated from the rhizomes of Polygonatum zanlanscianense, together with six known spirostanols (5-10) and a known megastigmane glycoside (11). Their structures were elucidated on the basis of spectroscopic analysis and the results of acidic and enzymatic hydrolysis. The cytotoxic activities of 1-11 against HeLa cells are described.