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Updated: Aug 20, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Long-term outcome of augmentation of the maxillary sinus using deproteinised bone particles experimental study in
Hui Xu1, Yoshinaka Shimizu, Ken Onodera
1Division of Oral Pathology, Tohoku University Graduate School of Dentistry, Sendai, Japan. huixu@yahoo.co.jp
Abstract:
We studied the long-term outcome of deproteinised bone particles for augmentation of the maxillary sinus in rabbits. Histologically, 64 weeks after implantation, most of the newly formed bone in the augmented spaces had been absorbed. Histomorphometric analysis showed a significant reduction in the area of bone and a significant increase in the area of bone marrow. There was no substantial change in the area of deproteinised bone particles. We conclude that deproteinised bone particles do not absorb with time and that the newly formed bone in the augmented space after implantation is not stable in the long-term.
