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Updated: Aug 20, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
Published on: October 16, 2019
Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging
1Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610-0244, USA.
Abstract:
Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potentials were recorded from CA3-CA1 synaptic contacts from hippocampal slices obtained from young (5-8 months) and aged (22-24 months) male Fischer 344 rats. Blockade of Ca(2+)-release from ICS by cyclopiazonic acid, thapsigargin, or ryanodine blocked LTD induction in aged rats. Impaired LTD was not simply due to a loss of a Ca(2+) source. The idea that ICS may play prominent role in regulating synaptic modifiability through regulation of cell excitability and the timing of pre and postsynaptic activity is discussed.
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