Glycemic index and load-dynamic dietary guidelines in the context of diseases

The concepts of glycemic index (GI) and glycemic load (GL) are among a new generation of so-called dynamic dietary guidelines. In contrast to classical static guidelines, these new guidelines do not primarily consider the absolute amount of energy or nutrient to be ingested within 24 h, but rather are focused on the postprandial response. It is claimed that low-GI and -GL diets favorably affect many noncommunicable diseases that are prevalent in developed countries, including type II diabetes, insulin resistance, obesity, cardiovascular disease (CVD), and cancer. During the past 20 years, considerable evidence has accumulated suggesting that low-GI or -GL diets indeed positively influence some but not all diseases. Because virtually no deleterious effects of low-GI and -GL diets have been documented thus far or are to be expected, the promotion of these diets should be considered in the management of noncommunicable diseases.