Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacologically active microcarriers: a tool for cell therapy.

V M Tatard1, M C Venier-Julienne, P Saulnier

  • 1INSERM U 646, Laboratoire d'ingénierie de la Vectorisation Particulaire, 10 rue André Boquel, 49100 Angers, France.

Biomaterials
|December 29, 2004
PubMed
Summary

Pharmacologically active microcarriers (PAM) enhance cell therapy by improving cell survival and differentiation. These biodegradable PLGA particles deliver proteins, supporting cell integration and function in host tissues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of supramaximal resection in glioblastoma: A review.

Neuro-Chirurgie·2026
Same author

Patch-based 3D U-Net and transfer learning for longitudinal piglet brain segmentation on MRI.

Computer methods and programs in biomedicine·2021
Same author

Assessment of operator performance during oocyte retrievals: residents' learning curve and continuous monitoring of senior physicians.

BMC medical education·2021
Same author

Security and reliability of CUSTOMBONE cranioplasties: A prospective multicentric study.

Neuro-Chirurgie·2021
Same author

Triamcinolone acetonide-loaded lipid nanocapsules for ophthalmic applications.

International journal of pharmaceutics·2019
Same author

Acute intracranial hypertension management in metastatic brain tumor: A French national survey.

Neuro-Chirurgie·2019

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Regenerative Medicine

Background:

  • Cell therapy faces challenges including poor cell survival, differentiation, and integration.
  • Existing methods lack controlled delivery of therapeutic proteins to support cell function.
  • Biodegradable polymers offer potential for developing advanced cell delivery systems.

Purpose of the Study:

  • To develop and characterize novel pharmacologically active microcarriers (PAM) for enhanced cell therapy.
  • To create a system for controlled protein delivery to support cell survival, differentiation, and integration.
  • To optimize PAM for effective cell culture and delivery.

Main Methods:

  • Fabrication of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microcarriers.

Related Experiment Videos

  • Coating microcarriers with adhesion molecules for cell attachment.
  • Incorporation of nerve growth factor (NGF) for controlled protein release.
  • Characterization of microcarrier size, coating efficiency, and cell adhesion (PC12 cells).

    • Main Results:

    • Successfully produced NGF-releasing PAM capable of supporting PC12 cell adhesion and differentiation.
    • Demonstrated the potential of PAM to facilitate sympathetic-like neuronal differentiation and dopamine release.
    • Identified key parameters (size, coating, cell adhesion) for optimizing PAM functionality.

    Conclusions:

    • Pharmacologically active microcarriers (PAM) represent a promising tool to overcome limitations in cell therapy.
    • PAM can enhance cell survival, differentiation, and integration through controlled protein delivery.
    • Optimized PAM holds potential for advancing neural regeneration and other cell-based therapies.