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Related Experiment Videos

Thyroid paraganglioma.

R E Brownlee1, W W Shockley

  • 1Division of Otolaryngology-Head and Neck Surgery, University of North Carolina-Chapel Hill 27599-7070.

The Annals of Otology, Rhinology, and Laryngology
|April 1, 1992
PubMed
Summary
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Thyroid and laryngeal paragangliomas are rare tumors. This review suggests a common origin, advocating for revised nomenclature and confirming surgery as the preferred treatment with no reported recurrences.

Area of Science:

  • Endocrinology
  • Oncology
  • Head and Neck Surgery

Background:

  • Paragangliomas are rare neuroendocrine tumors originating from extra-adrenal chromaffin cells.
  • Thyroid paragangliomas are exceptionally rare, with limited documented cases.
  • Understanding the origin and behavior of these neoplasms is crucial for diagnosis and management.

Observation:

  • This study reviews eight previously reported cases of thyroid paraganglioma and presents an additional case with laryngeal involvement.
  • The review highlights the rarity of these tumors and their potential extension to adjacent structures like the larynx and trachea.
  • Comparison of laryngeal and thyroid paragangliomas suggests a potential shared anatomic and embryologic origin.

Findings:

  • The analysis indicates a possible common origin for laryngeal and thyroid paragangliomas, prompting a recommendation for nomenclature revision.

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  • Surgery is identified as the primary treatment modality for these paragangliomas.
  • Despite the small number of reported cases, adequate surgical excision has shown no instances of distant metastasis or local recurrence.

    • Implications:

    • Revised nomenclature could improve the classification and understanding of these rare tumors.
    • The findings support surgical intervention as a safe and effective treatment for thyroid and laryngeal paragangliomas.
    • Further research into the embryologic origins may elucidate diagnostic and therapeutic strategies for paragangliomas in this region.