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Eosinophilic leukemic transformation in polycythemia rubra vera (PRV)
1University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. jcschim@hkucc.hku.hk
Leukemia & Lymphoma
|December 29, 2004
Abstract:
We report a rare case of eosinophilic leukemia transformation in a patient with polycythemia rubra vera on hydroxycarbamide (hydroxyurea) therapy only. Cytogenetic study showed complex abnormalities including -5, -7, +8, suggestive of a secondary leukemia. The leukemogenic risk of hydroxycarbamide, a ribonucleoside reductase, and the risk of natural leukemic transformation of polycythemia rubra vera is discussed in the context of previous PVSG studies.