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Related Experiment Videos

Human herpes simplex virus keratitis: the pathogenesis revisited.

Lies Remeijer1, Albert Osterhaus, Georges Verjans

  • 1The Rotterdam Eye Hospital, Cornea and External Disease Service, Rotterdam, The Netherlands. schoerem@bart.nl

Ocular Immunology and Inflammation
|December 29, 2004
PubMed
Summary

Human herpes simplex virus 1 (HSV-1) causes significant eye disease and is the leading cause of corneal blindness. This review explores HSV-1

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Area of Science:

  • Ophthalmology
  • Virology
  • Immunology

Background:

  • Human herpesviruses cause substantial ocular morbidity.
  • Herpes simplex virus 1 (HSV-1) is the primary cause of infectious eye disease, leading to recurrent keratitis.
  • Recurrent HSV-1 keratitis remains a major cause of corneal blindness globally, despite antiviral therapies.

Purpose of the Study:

  • To review current knowledge on the pathogenesis of HSV-1 keratitis.
  • To elucidate the role of the virus and intra-corneal T cell responses in disease development.

Main Methods:

  • Literature review of studies on HSV-1 ocular infections.
  • Analysis of viral mechanisms and host immune responses, particularly T cell involvement in the cornea.

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Main Results:

  • HSV-1 is a significant pathogen in ocular infections.
  • Intra-corneal T cell responses play a critical role in the pathogenesis of HSV-1 keratitis.

Conclusions:

  • Understanding HSV-1 pathogenesis and T cell responses is crucial for managing ocular disease.
  • Further research into these areas may lead to improved therapeutic strategies for preventing corneal blindness.