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Related Experiment Videos

Neurophysiologic studies in Morvan syndrome.

Keith A Josephs1, Michael H Silber, Robert D Fealey

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA. josephs.keith@mayo.edu

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|December 29, 2004
PubMed
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Morvan syndrome, an autoimmune disorder, affects the nervous system causing peripheral neuropathy, autonomic dysfunction, and severe insomnia. Neuroimaging is often normal, suggesting functional disruption.

Area of Science:

  • Neurology
  • Immunology
  • Neurophysiology

Background:

  • Morvan syndrome is a rare autoimmune disorder.
  • It affects both the peripheral and central nervous systems.
  • Characterized by hyperexcitability, autonomic dysfunction, and severe insomnia.

Observation:

  • Two cases of Morvan syndrome were reviewed.
  • Neurophysiologic studies included polysomnography, autonomic testing, MRI, PET, EEG, and SPECT.
  • Patients had high levels of voltage-gated potassium channel antibodies.

Findings:

  • Peripheral autonomic neuropathy and autonomic hyperactivity were observed.
  • Complete absence of sleep was noted on polysomnography.
  • Neuroimaging studies were largely normal, indicating functional disruption.

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Implications:

  • Morvan syndrome involves both peripheral and central nervous system autoimmunity.
  • Neurophysiologic findings highlight nerve hyperexcitability, autonomic dysfunction, and insomnia.
  • Normal imaging suggests functional rather than structural neural network disruption in CNS symptoms.