[Pulmonary gas exchange during exercise in healthy subjects]

The modifications of gas exchange on exercise reflect the consequences of the control and limits of adaptation of the respiratory apparatus to the mechanical loads imposed on the muscles and the oxygen requirements of the organism. In the majority of cases, even if the thoraco-pulmonary apparatus is perfectly adapted to the increase in these requirements, the balance between the metabolic demands of the tissues and the pulmonary supply appears difficult to satisfy beyond certain limits without hypoxaemia, particularly in those subjects with a low ventilatory response to exercise. Based on the populations reported in the literature the functional limits of the control of the thoraco-pulmonary system and the possible modifications of the structures of the lung are discussed for each of these mechanisms.

At certain levels of duration and intensity of exercise there is an increase in the alveolar-arterial oxygen gradient [P(A-a)O2] associated inconsistently with a fall in PaO2. It is mainly the use of inert gas techniques that has established over many years the respective roles of the different possible patho-physiological mechanisms: shunt, unequal distribution of VA/Q ratios, limitation of alveolar-capillary diffusion and its components. The inequalities of VA/Q increase at low levels of exercise but beyond certain levels of VO2 limitation of oxygen diffusion may develop. In effect, particularly in subjects capable of high levels of exercise, the interaction between diminished transit time of the red cells in the pulmonary capillaries and possible delay in equilibration of partial pressures between the blood and gas phases may create a limitation of diffusion. This added to the inequalities of distribution of VA/Q and reduction in PVO2 leads, in certain subjects, to a transitory exercise induced hypoxaemia.

New techniques of investigation seem to be necessary to clarify the sources of the observed changes and the development of modifications of pulmonary structure that establish the functional limits of the lungs on exercise. It remains to demonstrate the true impact of these anomalies on the limitation of human performance.