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Updated: Aug 20, 2026
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
[Immunological effects of polyacrylamide hydrogel injection in human body]
Xiao-ling Feng1, Chuan-xun Yi, Yi-ming Zhang
1Department of Plastic Surgery, Union Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Objective:
To observe the immunologic changes in patients who have complications after polyacrylamide hydrogel (HPG) injection.
Methods:
To compare the patients in the HPG injection group and the control group, the expressions of immunoglobulin IgG, IgM, IgA and complement C3, C4 of serum were measured by immunoturbidimetry.
Results:
The expressions of IgG and C3 in the injection group were lower than the control group with extremely significant difference (P < 0.01). The expressions of IgM were higher than the control group with significant difference (P < 0.05). The expression of IgA and C4 had no significant differences between the two groups. The immunologic changes had no relation to the injection doses.
Conclusions:
Clinical application of HPG as a soft tissue filling material may cause foreign-body rejection reaction. The long-term immunologic effect of HPG needs further observation in more cases.
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