Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural abnormalities remote from the seizure focus: a study using T2 relaxometry at 3 T.

R S Briellmann1, G D Jackson, G S Pell

  • 1Brain Research Institute, Austin Health, Melbourne, Australia.

Neurology
|December 30, 2004
PubMed
Summary

Partial epilepsy patients show abnormal T2 relaxation times in mesial temporal and subcortical areas, indicating signal changes beyond the seizure focus. These MRI findings suggest non-localized abnormalities in epilepsy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative MRI as an imaging marker of concussion: evidence from studying repeated events.

European journal of neurology·2020
Same author

Computational Identification of Tumor Anatomic Location Associated with Survival in 2 Large Cohorts of Human Primary Glioblastomas.

AJNR. American journal of neuroradiology·2016
Same author

Manual hippocampal volumetry is a better detector of hippocampal sclerosis than current automated hippocampal volumetric methods.

AJNR. American journal of neuroradiology·2013
Same author

Arterial spin-labeled perfusion of pediatric brain tumors.

AJNR. American journal of neuroradiology·2013
Same author

EEG-fMRI in focal epilepsy: local activation and regional networks.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2013
Same author

Bilateral posterior periventricular nodular heterotopia: a recognizable cortical malformation with a spectrum of associated brain abnormalities.

AJNR. American journal of neuroradiology·2013

Area of Science:

  • Neuroimaging
  • Epilepsy Research
  • Radiology

Background:

  • Partial epilepsy is a common neurological disorder.
  • Understanding the full extent of brain abnormalities in epilepsy is crucial for diagnosis and treatment.
  • Mesial temporal structures and subcortical regions are often implicated in epilepsy.

Purpose of the Study:

  • To investigate the extent and severity of signal abnormalities in mesial temporal and subcortical regions in patients with partial epilepsy.
  • To differentiate signal abnormalities based on epilepsy etiology (hippocampal sclerosis, malformations of cortical development, normal MRI).

Main Methods:

  • Acquired T2 relaxation time maps using 3 Tesla MRI in 50 epilepsy patients and 55 controls.
  • Analyzed eight bilateral brain regions: hippocampus, anterior temporal lobe (ATL) white matter, amygdala, frontal lobe white matter, caudate, putamen, pallidum, and thalamus.

Related Experiment Videos

  • Classified patients into hippocampal sclerosis (HS), malformations of cortical development (MCD), or normal MRI groups.

    • Main Results:

    • Patients with HS showed increased T2 times in the ipsilateral hippocampus and ATL.
    • Patients with MCD exhibited increased T2 times in the temporal lobe and subcortical areas (caudate, putamen, pallidum).
    • Patients with normal MRI had increased T2 times in the hippocampus and putamen; no correlation with epilepsy duration or seizure load was found.

    Conclusions:

    • Increased T2 relaxation times are present in mesial temporal structures in epilepsy, even with seizure foci remote from the hippocampus.
    • Subcortical structures show increased T2 relaxation times in patients with normal MRI and focal malformations of cortical development.
    • These T2 relaxation time abnormalities extend beyond the primary seizure focus and are not solely secondary effects of seizures.