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Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease

J Olazarán1, R Muñiz, B Reisberg

  • 1Fundación Maria Wolff, Madrid, Spain.

Neurology
|December 30, 2004
PubMed
Abstract

Insights

A cognitive-motor intervention (CMI) program helped maintain cognitive function and improve mood in early Alzheimer

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Psychology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
  • Cholinesterase inhibitors (ChEIs) are a common treatment for AD.
  • Cognitive and motor decline are hallmark symptoms of AD.

Purpose of the Study:

  • To assess the effectiveness of a cognitive-motor intervention (CMI) program.
  • To evaluate CMI in early-stage Alzheimer's disease patients receiving ChEI therapy.
  • To determine if CMI offers additional benefits beyond standard care.

Main Methods:

  • Randomized controlled trial involving patients with mild cognitive impairment, mild AD, and moderate AD.
  • Experimental group received psychosocial support plus a 1-year CMI program (cognitive exercises, social, and psychomotor activities).
  • Control group received psychosocial support alone; efficacy measured by ADAS-cog, MMSE, FAQ, and GDS at multiple time points.

Main Results:

  • Patients in the CMI group maintained cognitive status at 6 months, unlike the control group.
  • Cognitive benefits were more pronounced in patients with less formal education.
  • Significantly more patients in the CMI group maintained or improved their affective status at 12 months (75% vs. 47%).

Conclusions:

  • A long-term cognitive-motor intervention provides additional cognitive and mood benefits for early Alzheimer's disease patients on ChEI treatment.
  • CMI may be a valuable adjunctive therapy for managing Alzheimer's disease.
  • Further research into tailored CMI programs based on educational background may be warranted.

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