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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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Primary hyperparathyroidism in pregnancy

M Amaya García1, M Acosta Feria, A Soto Moreno

  • 1Department of Endocrinologyetrics and Gynecology, Hospitales Universitarios Virgen del Rocío, Seville, Spain. mariajoseamaya@eresmas.com

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|December 31, 2004
PubMed

Gestational primary hyperparathyroidism presents with features which, from a physiological and prognostic viewpoint, entail great difficulty in diagnosis and a high risk of complications. These complications occur at rates of 67% and 80% in the mother and fetus, respectively, and can be reduced by up to four times by means of prompt application of effective therapeutic measures. We report a case involving a pregnant woman in the 16th week of gestation who presented with asymptomatic hypercalcemia secondary to a solitary parathyroid adenoma. When the patient did not improve after conservative therapeutic measures, it was decided to employ surgical treatment in the second trimester of pregnancy. The surgery was successful, and the follow-up period was without complications for the mother and neonate. We therefore agree with the growing evidence that surgery in the second trimester of pregnancy constitutes a safe and effective alternative to conservative treatment.

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