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Immune traffic: a functional overview

Andreas Beilhack1, Stanley G Rockson

  • 1Department of Medicine (Bone Marrow Transplantation) and Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

Lymphatic Research and Biology
|December 31, 2004
PubMed

The efficient function of the immune system necessitates the complex interaction of antigens, antigen-presenting cells, and cell populations that modulate, regulate and effectuate the immune response. In order to overcome the spatial limitations that are imposed by the constraints of the system, the immune system has evolved a dependence upon the lymphatic vasculature to serve the biological needs of immune trafficking. This review will focus upon useful ex vivo and intact animal models that possess the ability to provide valuable information about leukocyte trafficking.

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