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Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Swim training increases ovalbumin induced active systemic anaphylaxis in mice
1Division of Sports and Well-Being, College of Human Movement Sciences, Hanyang University-Ansan, Kyunggi-do, South Korea.
Immunological Investigations
|December 31, 2004
Summary
Regular swim training in mice decreased body weight but increased spleen index, allergic responses, and IL-4 levels. This suggests a link between aerobic exercise and allergy anaphylaxis.
Area of Science:
- Immunology
- Exercise Physiology
Background:
- Aerobic training enhances oxygen intake and benefits physical condition.
- Elite athletes may experience bronchial symptoms, exercise-induced asthma, and active systemic anaphylaxis.
- The relationship between exercise and allergic responses requires further investigation.
Purpose of the Study:
- To investigate the effects of regular swim training on allergic responses in BALB/c mice.
- To examine changes in body weight, spleen index, lymphocyte proliferation, and cytokine levels post-training.
Main Methods:
- Thirty BALB/c mice were divided into control, sensitized, and sensitized-trained groups.
- The sensitized-trained group underwent 10 weeks of regular swim training.
- Measurements included body weight, spleen index, lymphocyte proliferation (ovalbumin-stimulated), and cytokine levels (IL-4).
Main Results:
- Swim training led to decreased body weight (p < .05).
- Significant increases were observed in spleen index, active systemic anaphylaxis scores, ovalbumin-stimulated lymphocyte proliferation, and IL-4 levels in the trained group compared to the sensitized group (p < .05).
Conclusions:
- Regular swim training is linked to heightened allergic anaphylaxis responses.
- Increased lymphocyte proliferation, active systemic anaphylactic shock scores, and IL-4 levels may mediate this effect.
