Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calciotropic hormones during reproduction.

J Verhaeghe1, R Bouillon

  • 1Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Catholic University of Leuven, Belgium.

The Journal of Steroid Biochemistry and Molecular Biology
|March 1, 1992
PubMed
Summary

Hormonal changes during the menstrual cycle, pregnancy, and lactation impact calciotropic hormones like parathyroid hormone (PTH) and 1,25(OH)2D. Pregnancy and prolonged lactation significantly increase these hormones, affecting calcium absorption.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaginal Er:YAG laser application in the menopausal ewe model: a randomised estrogen and sham-controlled trial.

BJOG : an international journal of obstetrics and gynaecology·2020
Same author

Consensus statement from 2<sup>nd</sup> International Conference on Controversies in Vitamin D.

Reviews in endocrine & metabolic disorders·2020
Same author

Calcifediol or vitamin D to optimize vitamin D status: Reply to letter of M Sosas.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Vitamin D and cardiovascular disorders.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC).

NeuroImage. Clinical·2019
Same author

Sunscreen photoprotection and vitamin D status.

The British journal of dermatology·2019

Area of Science:

  • Endocrinology
  • Reproductive Physiology
  • Mineral Metabolism

Background:

  • Serum concentrations of calciotropic hormones, parathyroid hormone (PTH), and 1,25(OH)2D, are crucial for calcium homeostasis.
  • The menstrual cycle, pregnancy, and lactation represent distinct physiological states that may influence these hormones.

Purpose of the Study:

  • To review and synthesize the existing literature on the effects of the menstrual cycle, pregnancy, and lactation on serum PTH and 1,25(OH)2D concentrations.
  • To elucidate the hormonal mechanisms and physiological consequences of these changes.

Main Methods:

  • Literature review of studies examining serum concentrations of PTH and 1,25(OH)2D during different reproductive stages.
  • Analysis of reported changes in hormone levels and their potential regulation.

Related Experiment Videos

Main Results:

  • Menstrual cycle effects on PTH and 1,25(OH)2D are inconsistent, with some studies noting a midcycle rise, but most showing no significant change.
  • Pregnancy is associated with increased total and free 1,25(OH)2D, likely due to stimulated renal production and potentially placental/fetal contributions, leading to enhanced intestinal calcium absorption.
  • Postpartum levels of PTH and 1,25(OH)2D drop, but rise again with prolonged lactation or in mothers nursing multiples, possibly stimulated by PTH and prolactin.

Conclusions:

  • Pregnancy and lactation significantly alter calciotropic hormone levels, adapting calcium metabolism to meet increased demands.
  • While the menstrual cycle's impact is less clear, pregnancy and lactation demonstrate robust hormonal regulation of calcium homeostasis.
  • Further research is needed to fully clarify the role of placental/fetal production and the precise regulation of PTH during pregnancy.