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Circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 are associated with early
Shin-ichi Kawachi1, Noriyuki Takeda, Akihiko Sasaki
1Department of Diabetes and Endocrinology, Medical Sciences Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. kawachi@cc.gifu-u.ac.jp
Insights
Increased levels of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) are linked to early carotid atherosclerosis in Japanese men. These factors may promote the development of atherosclerosis.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Metabolic Syndrome
Background:
- The growth hormone (GH)-insulin-like growth factor (IGF)-1 axis influences vascular and cardiac cell function.
- The precise role of the GH-IGF-1 axis in cardiovascular disease remains debated.
Purpose of the Study:
- To investigate the association between circulating levels of IGF-1 and IGFBP-3 with early carotid atherosclerosis.
- To examine the relationship of IGF-1 and IGFBP-3 with traditional atherosclerotic risk factors.
Main Methods:
- Cross-sectional study of 330 Japanese men.
- Measurement of carotid intima-media thickness (IMT) via ultrasound.
- Assessment of abdominal adipose tissue (visceral and subcutaneous) using computed tomography.
- Partial correlation analysis to determine associations.
Main Results:
- Circulating IGF-1 and IGFBP-3 levels were positively associated with body mass index and plasma insulin.
- IGF-1 correlated with subcutaneous adipose tissue and inversely with high-density lipoprotein cholesterol.
- IGFBP-3 showed positive associations with blood pressure, total cholesterol, and visceral adipose tissue.
- Both IGF-1 and IGFBP-3 were independently associated with carotid IMT, suggesting a direct role in atherosclerosis development.
Conclusions:
- Elevated circulating IGF-1 and IGFBP-3 may act as accelerators of atherosclerosis.
- These findings contribute to understanding the complex role of the GH-IGF-1 axis in cardiovascular pathology.
Objective:
Growth hormone (GH)-insulin-like growth factor (IGF)-1 axis regulates growth and survival of vascular cells and cardiomyocytes. The role of GH-IGF-1 axis in cardiovascular disease is controversial.
Methods And Results:
We assessed the association of circulating levels of IGF-1 and IGF binding protein-3 (IGFBP-3) with early carotid atherosclerosis and atherosclerotic risk factors in 330 Japanese men (age 51.6+/-8.6 years, range 29 to 77, body mass index [BMI] 23.6+/-2.9 kg/m2). Intima-media thickness (IMT) of the common carotid artery was measured by ultrasound. Abdominal visceral adipose and subcutaneous adipose tissue area by computer-assisted tomographic scan were determined. Correlation coefficients were calculated by partial correlation analysis. BMI and plasma insulin showed positive associations with circulating IGF-1 and IGFBP-3. Subcutaneous adipose tissue was correlated with IGF-1. High-density lipoprotein cholesterol was inversely associated with IGF-1. Blood pressure, total cholesterol, triglyceride, and visceral adipose tissue were positively associated with IGFBP-3. IGF-1 and IGFBP-3 were associated with carotid IMT independent of age, BMI, blood pressure, and insulin. Insulin was associated with carotid IMT in univariate analysis. However, it was not correlated with carotid IMT in the multivariate analyses which included IGF-1 or IGFBP-3 as a covariate.
Conclusions:
Increased circulating IGF-1 and IGFBP-3 may be stimulators of atherosclerosis.
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