[A severe case of nephrotic syndrome]

A 14-year-old girl presented at the Renal Unit with clinical and laboratory pictures of a severe nephrotic syndrome. It was done a kidney biopsy which detected a picture of "minimal change". As the patient had no benefit from the prednisone therapy, she underwent to another biopsy which detected, this time, a Focal Glomerulosclerosis. Despite the immunosuppressive therapy, the renal function deteriorated and, therefore, the patient began dialysis. After a while, the girl received a cadaveric kidney transplantation but the nephrotic syndrome recurred again and the patient went back to chronic dialysis.