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Updated: Aug 20, 2026

Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
Published on: September 9, 2021
The formation of carbon monoxide during peroxidation of microsomal lipids
1Department of Pharmacology, University of Southern California, School of Medicine, Los Angeles, California 90033, USA.
Abstract:
The evolution of carbon monoxide during lipid peroxidation has been demonstrated in microsomal membranes. The formation of carbon monoxide was dependent on the peroxidation process, but independent of the initiators (NADPH-ADP x Fe(+3) or Ascorbate-Fe(+3)) used. Contrary to published results, the carbon monoxide does not result from heme catabolism. Carbon monoxide was generated during the peroxidation of isolated phospholipids, indicating that carbon monoxide may form directly during the peroxidative degradation of unsaturated fatty acids.
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