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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Stimulation of human peripheral blood lymphocytes by a sodium periodate (NaIO4) induced growth factor
T M Monahan1, A F Frost, C W Abell
1Department of Human Biological Chemistry and Genetics,The University of Texas Medical Branch Galveston, Texas 77550, USA.
Abstract:
Sodium periodate treated lymphocytes engage in cell to cell interaction and also yield a soluble growth factor that stimulates DNA synthesis when added to naive autologous cells. Adherent cells enhance the factor mediated activity. Sodium periodate stimulated lymphocytes, treated with mitomycin C, produced no growth factor activity. Partial characterization of the factor indicates that it is non-dialyzable, resistant to ribonuclease, and sensitive to heat, trypsin, and papain.
