Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Subungual neurothekeoma.

Maureen Connolly¹, James R Hickey, Laszlo Intzedy

¹Department of Dermatology, Bristol Royal Infirmary, United Kingdom.

Journal of the American Academy of Dermatology

|January 1, 2005

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Large cell acanthoma: A benign lesion masquerading as malignant melanoma.

Dermatology online journal·2026

Same author

A waxy wonder: unveiling a rare dermatological mystery.

Skin health and disease·2026

Same author

National clinical reaudit on managing adults with bullous pemphigoid 2024 highlighting shifting clinical practices.

Skin health and disease·2025

Same author

Unilateral Peri-Orbital Oedema and Mechanical Ptosis: An Unusual Case Presentation of Rosacea.

Case reports in ophthalmology·2025

Same author

Kickin' it with the Gurlz: An evaluation of an HIV status-neutral intervention designed to address violence and trauma among transgender women of color in Detroit.

Psychology of violence·2025

Same author

Prospective Analysis of Mesotheliomas in Subjects With BAP1 Cancer Syndrome: Clinical Characteristics and Epigenetic Correlates of Disease.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2025

Neurothekeomas, benign nerve sheath tumors, are rarely found on lower limbs. This report details the first known case of a subungual neurothekeoma on a big toe, confirmed by S100 protein staining.

Area of Science:

Dermatopathology
Oncology
Surgical Pathology

Background:

Neurothekeomas, also known as dermal nerve sheath myxomas, are benign tumors of probable nerve sheath origin.
Typically observed on the face, arms, or shoulders, they less commonly affect the lower extremities.

Observation:

This case presents the first documented instance of a subungual neurothekeoma.
The tumor was located on the big toe.

Findings:

Histopathological examination revealed a well-circumscribed, multilobulated tumor.
The tumor comprised bland stellate and spindle cells within an abundant myxoid matrix.
Immunohistochemistry confirmed positivity for S100 protein.

Implications:

Related Experiment Videos

This finding expands the known anatomical distribution of neurothekeomas.
It highlights the importance of considering neurothekeomas in the differential diagnosis of subungual tumors.
Further research may elucidate the specific pathogenesis and behavior of digital neurothekeomas.