Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brugada syndrome: from cell to bedside.

Charles Antzelevitch1, Pedro Brugada, Josep Brugada

  • 1Masonic Medical Research Laboratory, Utica, NY 13501, USA. ca@mmrl.edu

Current Problems in Cardiology
|January 1, 2005
PubMed
Summary

Brugada syndrome, a condition linked to sudden death in young people, is increasingly recognized. This review synthesizes current knowledge on its clinical, genetic, and cellular aspects, guiding diagnosis and therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biophysical Characterization of a Novel KCNJ8 Rare Variant Linked With Inherited and Acquired J Wave Syndrome.

JACC. Clinical electrophysiology·2026
Same author

Exploring sex-specific clinical features in Chinese patients with Takotsubo syndrome.

BMC cardiovascular disorders·2025
Same author

Characterization of novel arrhythmogenic patterns arising secondary to heterogeneous expression and activation of Nav1.8.

Frontiers in cardiovascular medicine·2025
Same author

The Efficacy of I Na Block to Cardiovert Atrial Fibrillation Is Enhanced by Inhibition of I K1.

Journal of cardiovascular pharmacology·2024
Same author

The potential anti-arrhythmic effect of SGLT2 inhibitors.

Cardiovascular diabetology·2024
Same author

Gene and stem cell therapy for inherited cardiac arrhythmias.

Pharmacology & therapeutics·2024

Area of Science:

  • Cardiology
  • Genetics
  • Molecular Biology

Background:

  • Brugada syndrome identified in 1992, characterized by high incidence and risk of sudden death in young individuals.
  • Significant increase in reported cases and research publications detailing clinical, genetic, cellular, ionic, and molecular aspects.
  • Two consensus conferences (2002, 2003) established diagnostic criteria and advanced understanding.

Purpose of the Study:

  • Provide a comprehensive review of Brugada syndrome.
  • Integrate findings from consensus conferences and recent scientific literature.
  • Outline current understanding of clinical, genetic, molecular, and cellular facets.

Main Methods:

  • Systematic review of clinical and basic science publications.
  • Incorporation of data from two international consensus conferences.

Related Experiment Videos

  • Synthesis of information on diagnostic criteria, risk stratification, and therapeutic approaches.

    • Main Results:

    • Established diagnostic criteria for Brugada syndrome.
    • Detailed understanding of genetic, molecular, and cellular mechanisms.
    • Development of risk stratification schemes and therapeutic strategies.

    Conclusions:

    • Brugada syndrome knowledge has rapidly evolved since its recognition.
    • Current diagnostic and therapeutic approaches are based on available evidence but require ongoing refinement.
    • Further molecular studies and prospective trials are essential for future advancements.