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Updated: Aug 20, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Videonasopharyngoscopy is useful for identifying children with Pierre Robin sequence and severe obstructive sleep
Gerardo Bravo1, Antonio Ysunza, José Arrieta
1Cleft Palate Clinic, Hospital Gea González, 4800 Calzada Tlalpan, Mexico City 14000, D.F., Mexico.
Insights
Videonasopharyngoscopy (VNP) effectively identifies severe obstructive sleep apnea syndrome (OSAS) in children with Pierre Robin sequence (PR). This safe and reliable tool aids in evaluating sleep-disordered breathing in this population.
Area of Science:
- Pediatric Otolaryngology
- Sleep Medicine
- Genetics and Rare Diseases
Background:
- Obstructive sleep apnea syndrome (OSAS) is common in children with Pierre Robin sequence (PR).
- Polysomnography (PS) is the standard for OSAS diagnosis.
- Videonasopharyngoscopy (VNP) visualizes the upper airway and identifies structural issues linked to OSAS.
Purpose of the Study:
- To assess the utility of VNP in identifying severe OSAS in children with PR.
Main Methods:
- Fifty-two children with PR and sleep-disordered breathing underwent VNP and PS.
- Evaluations included questionnaires, pediatric exams, and craniofacial assessments.
Main Results:
- OSAS was confirmed by PS in 31 patients.
- VNP demonstrated 87% sensitivity and 100% specificity for OSAS detection.
- VNP findings correlated significantly with OSAS severity metrics.
Conclusions:
- Airway obstruction in children with PR, identified by VNP, is a risk factor for OSAS.
- VNP is a safe and reliable method for evaluating sleep-disordered breathing in children with PR.
Introduction:
Obstructive sleep apnea syndrome (OSAS) commonly appears in patients with Pierre Robin sequence (PR). Polysomnography (PS) is the gold standard for the diagnosis of OSAS. Videonasopharyngoscopy (VNP) is the best diagnostic tool for visualizing the vocal tract and detecting structural abnormalities which can be associated with OSAS.
Objective:
The purpose of this paper is to study whether VNP can be useful for identifying severe OSAS in a population of children with PR.
Materials And Methods:
Fifty-two children with PR who were present with sleep-disordered breathing were studied. All the parents completed a questionnaire concerning the children's sleeping habits and sleep complaints before consultation. Each child underwent a general pediatric examination and an evaluation of craniofacial features and upper airway permeability. In all children, a PS was performed. Also, all children underwent a VNP.
Results:
The diagnosis of OSAS was confirmed by PS in 31 patients. VNP showed 87% sensitivity and 100% specificity for the detection of OSAS. VNP findings showed a significant correlation with apnea-hypopnea index, arousal index, snoring time, percentage of sleep time spent at saturation of oxygen <90% and a significant inverse correlation with total sleep time, sleep efficiency and the mean saturation of oxygen during sleep.
Conclusion:
This study shows that in children with PR, airway obstruction as detected by VNP seems to be a risk factor for OSAS. VNP appears to be a safe and reliable tool for the evaluation of sleep-disordered breathing in children with PR.
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