Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Saving infected catheters: why and how.

Michael Allon1

  • 1Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL 035294, USA. mdallon@uab.edu

Blood Purification
|January 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends in Vascular Access Placement among Patients Initiating Hemodialysis with a Catheter.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Comparative Epidemiology of KRT in the United States and Israel.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

The Role of Analysis Populations and Estimands in Clinical Trials.

Journal of the American Society of Nephrology : JASN·2026
Same author

Launching Kidney360: Reflections on an Editorial Journey as We Pass the Torch.

Kidney360·2025
Same author

Commemorating the National Institute of Diabetes and Digestive and Kidney Diseases' Advances in Kidney Health: 75 Years of Discovery and Impact.

Journal of the American Society of Nephrology : JASN·2025
Same author

Commemorating the National Institute of Diabetes and Digestive and Kidney Diseases' Advances in Kidney Health: 75 Years of Discovery and Impact.

Kidney360·2025
Same journal

Peritoneal Glucose Uptake Reduction by Sodium-Glucose Co-Transporter 2 Inhibitors in Clinical Peritoneal Dialysis.

Blood purification·2026
Same journal

With the Generalization of AI and Algorithms, Will We Still Need a Nephrologist in the Dialysis Room?

Blood purification·2026
Same journal

Could serum CA125 aid the clinical assessment of volume status of end-stage kidney disease patients treated by peritoneal dialysis patients?

Blood purification·2026
Same journal

From Bench to Bedside: Implications and Interventions for Endotoxin Exposure in Lipopolysaccharide-Induced Apoptosis and Eryptosis.

Blood purification·2026
Same journal

Feasibility Study of a Smartphone App and Web Portal for Remote Monitoring of Chronic Kidney Disease and Peritoneal Dialysis populations: A mixed-method study.

Blood purification·2026
Same journal

Treatment of Focal Segmental Glomerulosclerosis in Low- and Middle-Income Countries: Emerging Extracorporeal Therapies.

Blood purification·2026
See all related articles

An antibiotic lock protocol effectively treats dialysis catheter infections, potentially avoiding catheter removal in most patients. This approach preserves dialysis access and reduces treatment burdens.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Medical Devices

Background:

  • Dialysis catheter-related bacteremia (CRB) is commonly treated with systemic antibiotics and catheter removal.
  • This conventional approach causes patient discomfort, disrupts dialysis access, and incurs significant costs.
  • Bacterial biofilms in the catheter lumen are a primary cause of CRB.

Purpose of the Study:

  • To evaluate the efficacy of an antibiotic lock protocol for treating CRB.
  • To determine if the antibiotic lock protocol can salvage infected dialysis catheters, avoiding removal.
  • To assess the potential of this protocol to reduce the need for catheter replacement.

Main Methods:

  • Patients with CRB received an antibiotic-anticoagulant solution instilled into the catheter lumen (antibiotic lock).

Related Experiment Videos

  • Treatment success was defined by resolution of fever and negative surveillance blood cultures.
  • Catheter replacement was reserved for cases of treatment failure.

    • Main Results:

    • The antibiotic lock protocol was successful in approximately two-thirds of CRB cases.
    • Persistent fever or positive blood cultures indicated treatment failure, necessitating catheter replacement.
    • The protocol demonstrated a high success rate in managing CRB while preserving catheter function.

    Conclusions:

    • Routine use of an antibiotic lock protocol can significantly decrease the necessity for dialysis catheter replacement in patients with CRB.
    • This method offers a less burdensome and potentially more cost-effective alternative to conventional treatment.
    • Preserving dialysis access through catheter salvage is a key benefit of the antibiotic lock protocol.