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Centrofacial angiocentric lymphoma.

Beatriz Peral-Cagigal1, María Galdeano-Arenas, Juan Ignacio Crespo-Pinilla

  • 1Servicio Regional de Cirugía Oral y Maxilofacial, Hospital Universitario del Río Hortega, Valladolid, Spain. beaperal77@yahoo.es

Medicina Oral, Patologia Oral Y Cirugia Bucal
|January 4, 2005
PubMed
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Centrofacial angiocentric lymphoma, a rare and aggressive Non-Hodgkin's lymphoma (NHL), presents diagnostic challenges. This case study highlights extranodal T-cell lymphoma of the nasal type in an Ecuadorian patient.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Centrofacial angiocentric lymphoma is a rare lymphoid neoplasm.
  • It is an aggressive Non-Hodgkin's lymphoma (NHL) typically affecting the upper respiratory tract, predominantly the nasal cavity.
  • Diagnosis can be challenging due to non-specific clinical presentations, often requiring multiple biopsies.

Observation:

  • A case study of a female Ecuadorian patient presenting with hemifacial edema, chocolate-like rhinorrhea, and nasal obstruction.
  • Initial symptoms were unresponsive to a month of antibiotic and anti-inflammatory treatment.
  • The patient's demographic profile (age, ethnicity, gender) aligns with typical epidemiological data for this condition.

Findings:

  • Histological examination confirmed extranodal T-cell lymphoma of the nasal type, also known as T-cell angiocentric lymphoma.

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  • The patient's presentation mimicked more common conditions, delaying definitive diagnosis.
  • The aggressive nature of the lymphoma and its ominous prognosis (12-18 months average survival) were noted.

    • Implications:

    • Highlights the importance of considering rare lymphoid neoplasms in differential diagnoses for persistent facial and nasal symptoms.
    • Emphasizes the need for thorough histopathological evaluation when initial treatments fail.
    • Contributes to understanding the clinical and diagnostic spectrum of extranodal T-cell lymphoma in diverse populations.