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[Febrile neutropenia in children who have leukemia]
1Pedijatrijska Klinika, Klinicki Centar Univerziteta u Sarajevu.
Insights
Febrile neutropenia is a frequent complication in children with malignant diseases. Prompt antibiotic therapy is crucial, as infections, including sepsis, are common causes.
Area of Science:
- Pediatric Hematology-Oncology
- Infectious Diseases in Immunocompromised Patients
Context:
- Febrile neutropenia is a significant complication in children undergoing treatment for malignant conditions.
- Prompt recognition and management of fever are critical, as it is often indicative of infection.
- Established protocols for managing febrile neutropenia are essential for timely intervention.
Purpose:
- To analyze the incidence and causes of febrile neutropenia in pediatric leukemia patients.
- To identify common pathogens responsible for infections in this vulnerable population.
- To evaluate the microbiological findings in children with febrile neutropenia.
Summary:
- A study of 83 children with leukemia found that 49.4% experienced febrile neutropenia.
- Infections were identified in 65% of these cases, with sepsis being the most common.
- Commonly isolated pathogens included Gram-positive bacteria (55%), Gram-negative bacteria (25%), and fungi (20%).
Impact:
- Highlights the high prevalence of infections, including sepsis, in pediatric febrile neutropenia.
- Emphasizes the importance of microbiological investigations for targeted antimicrobial therapy.
- Underscores the need for strict isolation and aseptic techniques to prevent superinfections.
Introduction:
Neutropenia febriles are the most frequent complications during the hospital treatment of children who are ill of malignant. It is urgent state end each of feverish should be treated as infection, until it is proved as opposite. It is necessary immediately to begin with antibiotical therapy according to the algoritham for therapy of neutropenia febriles. Neutropenia febriles is caused by virus, bacteria and fungus infection.
Results:
It were 83 leukemia treated children on Hematooncology department of pediatrical Clinic in Sarajevo in period from 01.01.1997 until 31.12.2002. Neutropenia febriles were seen at 41 of children (49.4%). Between all of neutropenia febriles the causes were isolated at 27 children (65%). The most of them had sepsis, and at 40% of children had positive hemo-cultures. In the hemo-cultures the gr. positive causes were isolated at the 55% of children, gr. negative causes were isolated at 25% of children, and fungus were isolated at 20%. Between the other cultures urino-cultures were positive at 18.5% of children. RTG pulmo was isolated at 18.5%, smear pharyngs was isolated at 11%.
Conclusion:
In such state of patient it should be thought about the possibility of contamination of patient and protect him/her from superinfection, by him/her in isolation box and staff should take care about sepsis and antisepsis.
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