Related Experiment Video
Updated: Aug 10, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
[Lymphocytes sensitization to insulin in acute ischemic attacks]
Abstract:
The study aimed at investigation of frequency and character of lymphocyte sensitization to insulin in patients with acute disturbances of brain blood circulation (ADBBC). Fifty patients with ADBBC (38-with ischemic stroke, 5-with hemorrhagic stroke, 7-with transient ischemic attacks), 17 patients with cerebrovascular diseases (CVD) and 20 age- and sex-matched controls have been studied. Lymphocyte sensitization to insulin (LS) was revealed in 32 patients with stroke and in 5-with CVD. Direct LS to insulin occured in 6 patients with stroke, all of them having diabetes mellitus type I. Indirect LS to insulin, defectable after inhibition of the cells with histamine receptors (CHR) or prostaglandin synthetizing cells (PGSC), was found in 26 patients with stroke (10-with diabetes type 2, 8-with pre-diabetes, 8 non-diabetic) and in 5 patients with CVD. Indirect LS to insulin is a key factor in development of insulin resistance. High PGSC activity is associated with CVD and transient ischemic attacks and high CHR activity is associated with stroke. Diabetes mellitus caused a severer course of ADBBC, and arterial hypertension may result in the ADBBC development in one third of patients.
More Related Videos
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Related Concept Videos
Insulin Secretory Vesicles
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Type I Diabetes I: Introduction
Type I Diabetes II: Pathophysiology
Type II Diabetes II: Pathophysiology