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A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
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[Living donor liver transplantation for the patient with hepatocellular carcinoma]

Akinobu Taketomi1, Yuuji Soejima, Tomoharu Yoshizumi

  • 1Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 5, 2005
PubMed

Insights

Living donor liver transplants (LDLTx) for advanced liver cancer (hepatocellular carcinoma, HCC) are increasing in Japan. Exceeding Milan criteria, specific tumor factors increase HCC recurrence risk post-LDLTx.

Area of Science:

  • Hepatobiliary Surgery
  • Transplant Oncology
  • Hepatology

Context:

  • Over 3,000 living donor liver transplantations (LDLTx) performed in Japan since 1989.
  • Increasing trend of LDLTx for advanced hepatocellular carcinoma (HCC) in patients with severe liver cirrhosis.
  • LDLTx is considered for HCC when liver function is severely impaired or HCC is refractory to other treatments, often exceeding Milan criteria.

Purpose:

  • To analyze the outcomes of LDLTx for advanced HCC in Japan.
  • To identify risk factors for HCC recurrence in patients undergoing LDLTx beyond Milan criteria.

Summary:

  • LDLTx for advanced HCC demonstrated 1- and 3-year survival rates of 84.6% and 73.3%, respectively.
  • Independent risk factors for HCC recurrence after LDLTx, particularly when exceeding Milan criteria, include tumor size >5 cm, vascular invasion, poor histologic differentiation, and elevated PIVKA-II levels (>300 mAU/ml).

Impact:

  • Highlights the efficacy of LDLTx for advanced HCC, even beyond established criteria.
  • Identifies critical factors for HCC recurrence, guiding patient selection and post-transplant management.
  • Underscores the need for strategies to prevent HCC and hepatitis C recurrence to improve long-term graft and patient survival.

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