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Related Experiment Videos

3,4 Methylenedioxymethamphetamine-induced conditioned place preference (CPP) is mediated by endocannabinoid system.

D Braida1, S Iosuè, S Pegorini

  • 1Department of Pharmacology, Chemotherapy and Medical Toxicology, Faculty of Sciences, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy.

Pharmacological Research
|January 5, 2005
PubMed
Summary
This summary is machine-generated.

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Intracerebroventricular injections of 3,4-methylenedioxymethamphetamine (MDMA) induced a dose-dependent conditioned place preference in rats. The endocannabinoid system appears to mediate this appetitive effect.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • 3,4-methylenedioxymethamphetamine (MDMA) is known for its psychoactive effects.
  • Conditioned place preference (CPP) is a behavioral paradigm used to assess the rewarding properties of substances.
  • The role of the endocannabinoid system in MDMA's appetitive effects is not well understood.

Purpose of the Study:

  • To investigate the appetitive potential of intracerebroventricular (i.c.v.) injections of MDMA using a CPP procedure.
  • To determine the involvement of cannabinoid, opioid, and serotonin 5-HT3 receptors in MDMA-induced CPP.
  • To explore the role of the endocannabinoid system in MDMA's incentive learning effects.

Main Methods:

  • Rats received i.c.v. injections of various doses of MDMA (0.1-10 ng/rat).

Related Experiment Videos

  • A CPP procedure was employed to assess the rewarding effects of MDMA.
  • Pre-treatment with receptor antagonists (SR 141716A, naloxone, tropisetron) was used to block MDMA's effects.
  • The motor activity of MDMA was assessed to ensure observed effects were not due to stimulation.

    • Main Results:

    • MDMA induced a dose-dependent CPP at doses that did not cause motor stimulation.
    • Pre-treatment with CB1 cannabinoid antagonist SR 141716A, opioid antagonist naloxone, and serotonin 5-HT3 antagonist tropisetron blocked the CPP induced by MDMA.
    • SR 141716A was more effective than naloxone and tropisetron in blocking MDMA-induced incentive learning.
    • The antagonists alone did not induce place conditioning.

    Conclusions:

    • MDMA, at very low i.c.v. doses, induces a conditioned place preference in rats.
    • The endocannabinoid system, along with opioid and serotonin 5-HT3 systems, participates in the appetitive effects of MDMA.
    • Cannabinoid CB1 receptors play a significant role in mediating MDMA-induced incentive learning.