Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HIV-1 diversity versus HLA class I polymorphism.

Henry A F Stephens1

  • 1Institute of Urology and Nephrology, University College London, The Middlesex Hospital, Mortimer Street, London, UK. h.stephens@ucl.ac.uk

Trends in Immunology
|January 5, 2005
PubMed
Summary

Human leukocyte antigen (HLA) class I genes influence human immunodeficiency virus type 1 (HIV-1) diversity and disease progression. Specific HLA alleles are linked to immune responses controlling HIV-1 infection and the development of acquired immunodeficiency syndrome (AIDS).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spectrum of glucose-6-phosphate dehydrogenase (G6PD) mutations and trends in hemoglobin levels among adult dengue patients in Thailand.

PloS one·2025
Same author

Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais.

The Journal of infectious diseases·2020
Same author

HLA Class I Supertype Associations With Clinical Outcome of Secondary Dengue Virus Infections in Ethnic Thais.

The Journal of infectious diseases·2015
Same author

Distinct activation phenotype of a highly conserved novel HLA-B57-restricted epitope during dengue virus infection.

Immunology·2013
Same author

Immunogenetic surveillance of HIV/AIDS.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2012
Same author

Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans.

Scientific reports·2012

Area of Science:

  • Immunogenetics
  • Virology
  • Human Population Genetics

Background:

  • Human immunodeficiency virus type 1 (HIV-1) exhibits rapid diversification across diverse global populations.
  • Polymorphism in genes encoding class I human leukocyte antigens (HLA) is extensive and varies among ethnic groups.
  • Immune responses involving HLA class I molecules shape HIV-1 evolution and diversity.

Purpose of the Study:

  • To investigate the associations between HLA class I alleles and HIV-1 infection and acquired immunodeficiency syndrome (AIDS) progression.
  • To explore the role of specific HLA alleles in mediating immune responses against HIV-1.
  • To understand how HLA-driven immune responses impact HIV-1 diversity and clinical outcomes.

Main Methods:

  • Intra- and inter-ethnic comparative studies analyzing HLA class I allele, haplotype, and supertype associations.

Related Experiment Videos

  • Examination of immune responses, including cytotoxic T lymphocyte (CTL) activity, in relation to HIV-1 infection.
  • Investigation of peptide-binding properties of specific HLA alleles and their interaction with immune cells.

    • Main Results:

    • Reproducible associations found between HLA class I profiles and HIV-1 infection/AIDS development across populations.
    • HLA-B57 and related HLA-B58 supertype alleles linked to lower viral load and delayed AIDS onset in Caucasoids and Africans, potentially via CTL-mediated attenuation.
    • HLA-A11 associated with CTL responses against HIV-1 Nef in uninfected Southeast Asians, exhibiting unique peptide-binding and natural killer cell recognition properties.

    Conclusions:

    • HLA class I genetics significantly influence HIV-1 diversity, immune control, and AIDS progression.
    • Specific HLA alleles, such as HLA-B57 and HLA-A11, play critical roles in shaping host immune responses to HIV-1.
    • Understanding these HLA-HIV-1 interactions is crucial for developing effective immune-based strategies against HIV/AIDS.