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Updated: Aug 12, 2026

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
Published on: January 15, 2011
IL-7 and IL-15: therapeutic cytokines for immunodeficiency
Onder Alpdogan1, Marcel R M van den Brink
1Department of Medicine, Memorial Sloan-Kettering Cancer Center, 406D, Mailbox 111 1275 York Avenue, New York, NY 10021, USA.
Abstract:
Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in clinical medicine, a 'lymphoid growth factor' has not yet been established in clinical use. Several recent studies have proposed two candidate immunostimulatory cytokines: interleukin-7 (IL-7) and IL-15. In this Review, we discuss recent findings regarding the effects of IL-7 and IL-15 on lymphopoiesis and their potential use for the treatment of immunodeficiency.
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