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Gestational diabetes is associated with depressed adiponectin levels
John P Thyfault1, Elizabeth M Hedberg, Raymond M Anchan
1Department of Physiology, East Carolina University, Brody School of Medicine, Greenville, North Carolina 27858, USA.
Journal of the Society for Gynecologic Investigation
|January 5, 2005
Summary
Gestational diabetes, particularly classes A2 and B, is linked to lower adiponectin levels, a marker of insulin resistance. These findings mirror those seen in type II diabetes and obesity.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Maternal-Fetal Medicine
Background:
- Adiponectin, an adipocyte-secreted protein, plays a role in insulin sensitivity.
- Reduced adiponectin levels are associated with insulin resistance in obesity and type II diabetes.
Purpose of the Study:
- To investigate adiponectin levels in pregnant individuals with gestational diabetes mellitus (GDM).
- To evaluate the relationship between GDM severity and adiponectin concentrations.
Main Methods:
- Plasma adiponectin, insulin, and glucose levels were measured in term, gravid subjects.
- Participants included women with GDM (classes A1, A2, B) and healthy controls.
- Samples were collected immediately prior to delivery.
Main Results:
- Adiponectin levels were significantly lower in GDM classes A2 and B compared to controls.
- A non-significant decrease in adiponectin was observed in GDM class A1.
- Lower adiponectin levels were also noted in non-Caucasian subjects and diabetic non-Caucasian pregnant individuals.
Conclusions:
- Gestational diabetes mellitus classes A2 and B are associated with suppressed adiponectin levels.
- These findings suggest adiponectin may serve as a biomarker for insulin resistance in GDM.
- The results align with observations in other insulin-resistant states like type II diabetes and obesity.