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Related Experiment Videos

Carcinogenesis and mutagenesis by N-nitroso compounds having a basic center.

W Lijinsky1, R M Kovatch, J E Saavedra

  • 1ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702.

Cancer Letters
|April 15, 1992
PubMed
Summary
This summary is machine-generated.

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Two N-nitroso compounds were tested for carcinogenicity. Methylnitrosamino-N,N-dimethylethylamine (MNDMEA) caused esophageal tumors in rats, while dimethylaminoethylnitrosoethylurea (DMENEU) induced uterine and mammary tumors in female rats.

Area of Science:

  • Toxicology
  • Carcinogenesis
  • Organic Chemistry

Background:

  • N-nitroso compounds are a class of chemicals known for their potential carcinogenicity.
  • The basic nature of N,N-dimethylethylenediamine derivatives was investigated for its influence on carcinogenic activity.

Purpose of the Study:

  • To evaluate the carcinogenic potential of two N-nitroso compounds: methylnitrosamino-N,N-dimethylethylamine (MNDMEA) and N,N-dimethylaminoethylnitrosoethylurea (DMENEU).
  • To determine the target organs and susceptibility of different species (rats and hamsters) to these compounds.

Main Methods:

  • Oral administration of MNDMEA and DMENEU to male and female F344 rats via gavage.
  • Administration of MNDMEA to Syrian hamsters and rats via gavage and in drinking water.
  • Observation and documentation of tumor development and survival rates.

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Main Results:

  • MNDMEA induced esophageal and nasal tumors in rats, with rapid mortality.
  • Hamsters showed lower susceptibility to MNDMEA, developing nasal, liver, lung, and colon tumors.
  • DMENEU exhibited weak carcinogenicity in rats, causing uterine and mammary tumors in females, with no specific target organ in males.

Conclusions:

  • The basic center in these N-nitroso compounds does not impede their absorption or cellular entry.
  • These compounds can transform cells and induce tumor formation, highlighting their carcinogenic potential.