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Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage
Kenneth J Mukamal1, Alberto Ascherio, Murray A Mittleman
1Beth Israel Deaconess Medical Center, Harvard School of Public Health, Massachusetts General Hospital, and Brigham and Women's Hospital, Boston, Massachusetts 02215, USA. kmukamal@bidmc.harvard.edu
Annals of Internal Medicine
|January 5, 2005
Summary
Light to moderate alcohol consumption showed no increased risk for ischemic stroke in men. However, drinking patterns and beverage type, particularly red wine, influenced risk. Heavy drinking (over 2 drinks daily) may elevate stroke risk.
Area of Science:
- Cardiovascular epidemiology
- Alcohol and health
Background:
- The relationship between alcohol consumption and ischemic stroke risk is debated.
- Beverage type and drinking patterns may influence this association.
Purpose of the Study:
- To investigate the association between alcohol drinking patterns, beverage type, and ischemic stroke risk in men.
Main Methods:
- Prospective cohort study of 38,156 US male health professionals.
- Alcohol intake (beer, wine, liquor) assessed via food-frequency questionnaire every 4 years.
- Consumption categorized as light (<1 drink/day), moderate (1-2 drinks/day), and heavier (≥3 drinks/day).
Main Results:
- During 14-year follow-up, 412 ischemic strokes occurred.
- Light and moderate drinkers showed no increased risk compared to abstainers.
- Heavier drinking (≥3 drinks/day) was associated with a trend towards increased risk (RR 1.42).
- Drinking 1-2 drinks/day on 3-4 days/week showed the lowest risk (RR 0.68).
- Red wine consumption was inversely associated with risk in a dose-dependent manner.
Conclusions:
- Light to moderate alcohol intake was generally not linked to increased ischemic stroke risk in this male cohort.
- Drinking patterns and beverage type (e.g., red wine) may modify stroke risk.
- Consuming more than 2 alcoholic drinks daily might be associated with a higher risk of ischemic stroke.
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