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Related Experiment Videos

Do developing B cells need antigen?

Jean-Claude Weill1, Claude-Agnès Reynaud

  • 1INSERM U373, Faculté de Médecine René Descartes, 75730 Paris Cedex 15, France. weill@necker.fr

The Journal of Experimental Medicine
|January 5, 2005
PubMed
Summary
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B cell selection in the periphery is not driven by specific stimuli, contrary to T cell selection in the thymus. Mature B cell subsets, however, may face distinct selective pressures influencing their development.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • T cell selection occurs via MHC-peptide complexes in the thymus.
  • A similar selection process for B cells by self or commensal bacterial epitopes has been proposed.
  • This proposed B cell selection would shape their recognition of pathogen structures.

Purpose of the Study:

  • To investigate the selective pressures on B cell populations.
  • To determine if B cell repertoire entering the periphery is shaped by specific stimuli.

Main Methods:

  • Analysis of B cell repertoires.
  • Investigation of peripheral B cell populations.

Main Results:

  • The repertoire of B cells entering the periphery is not shaped by specific stimuli.

Related Experiment Videos

  • Mature B cell subsets appear to be under different selective pressures.

    • Conclusions:

    • B cell selection differs from T cell selection.
    • Peripheral B cell selection is not stimulus-driven but may involve pressures on mature subsets.