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Food-derived peptides and intestinal functions.

Makoto Shimizu1

  • 1Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. ams316@mail.ecc.u-tokyo.ac.jp

Biofactors (Oxford, England)
|January 5, 2005
PubMed
Summary

Food proteins and peptides have crucial roles in the gut, influencing nutrient absorption and immune responses. Understanding these interactions is key for developing effective functional foods.

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Area of Science:

  • Biochemistry
  • Nutrition Science
  • Gastroenterology

Background:

  • Food proteins and peptides exert diverse physiological functions beyond initial digestion.
  • Their roles within the intestinal tract, prior to absorption, are significant for nutrient uptake and cellular activity.
  • Examples include modulation of digestive enzymes, nutrient absorption, and immune responses.

Purpose of the Study:

  • To explore the functional roles of food-derived proteins and peptides within the intestinal tract.
  • To highlight their impact on nutrient absorption and cellular functions in the gut.
  • To emphasize the importance of understanding these interactions for functional food development.

Main Methods:

  • Review of existing research on food proteins and peptides in the intestinal tract.
  • Analysis of studies on specific peptides like casein-derived peptides and carnosine.
  • Observation of milk peptides potentially stimulating calcium transporters in intestinal cells.
  • Investigation of carnosine's effect on oxidative stress-induced inflammatory responses in intestinal cells.

Main Results:

  • Food proteins and peptides can regulate digestive enzyme activity, impacting nutrient absorption.
  • Casein-derived peptides enhance intestinal calcium absorption, serving as functional food ingredients.
  • Certain milk peptides may stimulate intestinal calcium transporters.
  • Carnosine suppresses inflammatory cytokine secretion in intestinal cells under oxidative stress.

Conclusions:

  • Dietary proteins and peptides play critical roles in intestinal health and function.
  • Their interactions within the gut influence nutrient absorption and immune modulation.
  • Further understanding of these mechanisms is essential for designing targeted functional foods.

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