Related Experiment Video

Updated: Aug 20, 2026

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

Green vegetable drink consumption protects peripheral lymphocytes DNA damage in Korean smokers

Myung-Hee Kang1, Yoo Kyoung Park, Hye-Young Kim

  • 1Department of Food and Nutrition, Hannam University, 133 Ojeong-dong, Daedeok-gu, Daejeon, Korea. mhkang@hannam.ac.kr

Biofactors (Oxford, England)
|January 5, 2005
PubMed

Insights

Smokers drinking a green vegetable juice daily for 8 weeks showed reduced DNA damage. This suggests the juice offers protection against oxidative stress and may have cancer-protective effects.

Area of Science:

  • Oxidative stress and DNA damage research
  • Nutritional science and disease prevention

Background:

  • Smoking is linked to increased free radical-mediated DNA damage, a factor in disease development.
  • Oxidative damage to DNA is a significant concern in smokers' health.

Purpose of the Study:

  • To investigate the protective effects of a green vegetable drink against DNA damage in smokers.
  • To determine if daily consumption of Angelica keiskei juice can reduce lymphocytic DNA damage.

Main Methods:

  • Twenty smokers participated in an 8-week supplementation study.
  • Participants consumed 240 ml of green vegetable drink daily.
  • DNA damage was assessed using the Comet assay, measuring tail length (TL), tail moment (TM), and percent DNA in tail.

Main Results:

  • An 8-week green vegetable drink regimen significantly reduced DNA damage in lymphocytes.
  • All measured parameters of DNA damage (TL, TM, % DNA in tail) showed significant improvement.
  • The results indicate a decrease in oxidative damage to DNA.

Conclusions:

  • Green vegetable drink consumption may offer a protective effect against DNA damage in smokers.
  • The study supports the hypothesis that this vegetable drink has cancer-protective properties.
  • Reduced oxidative DNA damage is a potential mechanism for the observed health benefits.

More Related Videos

Comet Assay as an Indirect Measure of Systemic Oxidative Stress08:23

Comet Assay as an Indirect Measure of Systemic Oxidative Stress

Published on: May 22, 2015

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation11:24

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Published on: July 3, 2015

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...