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Improving quality of life in asthmatic children

Abla M Albsoul-Younes1, Imad A Al-Doghim, Safan A Al-Safi

  • 1Department of Clinical Pharmacy, Jordan University of Science & Technology, King Hussein Medical Center, Jordan. ablabsou@just.edu.jo

Indian Journal of Pediatrics
|January 5, 2005
PubMed

Insights

Switching pediatric asthma patients to a budesonide/formoterol inhaler significantly improved their quality of life and asthma control. This new combination therapy also enhanced pulmonary function tests (PFTs).

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Pharmacotherapy

Background:

  • Pediatric asthma management often involves multiple inhalers.
  • Assessing quality of life is crucial for treatment efficacy in chronic conditions.
  • Budesonide/formoterol is a combination inhaler for asthma treatment.

Purpose of the Study:

  • To evaluate changes in quality of life for pediatric asthma patients switched to a budesonide/formoterol single inhaler.
  • To assess the impact of this switch on asthma control and pulmonary function.

Main Methods:

  • An open-label study involving 30 pediatric patients (6-15 years) with moderate to severe asthma.
  • Patients were switched from beclomethasone dipropionate to budesonide 160 mcg/formoterol 4.5 mcg (one inhalation twice daily).
  • Evaluations included pulmonary function tests (PFTs), asthma control indicators, and quality of life questionnaires at baseline and during follow-up.

Main Results:

  • A significant improvement in health-related quality of life was observed, with overall scores dropping from 1.75 to 0.80 (p<0.001).
  • Pulmonary function tests showed significant improvement: FEV1% increased from 62.7% to 87.4% and FVC% from 83.2% to 101.9% (p<0.001).
  • Better asthma control was also noted after the switch in therapy.

Conclusions:

  • Switching pediatric asthma patients from beclomethasone dipropionate to budesonide/formoterol in a single inhaler improves quality of life.
  • The combination therapy also demonstrated positive effects on clinical indices, including pulmonary function and asthma control.
  • This suggests budesonide/formoterol is an effective treatment option for improving outcomes in pediatric asthma.
Abstract

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