Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RNAi-mediated pathways in the nucleus.

Marjori A Matzke1, James A Birchler

  • 1Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, UZA2, Pharmazie Zentrum, Althanstrasse 14/2D-541, A-1090 Vienna, Austria. marjori.matzke@gmi.oeaw.ac.at

Nature Reviews. Genetics
|January 5, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRISPR-Cas9 Toolkit for Maize: Vector Design, Construction, and Analysis of Edited Plants.

Cold Spring Harbor protocols·2025
Same author

Genome imbalance modulates the expression of long non-coding RNAs in maize.

The Plant journal : for cell and molecular biology·2025
Same author

Genomic balance effects on gene expression and the organism.

Current opinion in plant biology·2025
Same author

Gene Dosage Sensitivity and Human Genetic Diseases.

Journal of inherited metabolic disease·2025
Same author

Global modulation of gene expression and transcriptome size in aneuploid combinations of maize.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Aneuploidy and ploidy variation conditioned by the B chromosome of maize.

Heredity·2025
Same journal

Molecular integration of seasonal temperature signals in flowering time control.

Nature reviews. Genetics·2026
Same journal

Revisiting retinal and macular degeneration in the genomics era.

Nature reviews. Genetics·2026
Same journal

Advancing the applications of liquid biopsies in oncology.

Nature reviews. Genetics·2026
Same journal

Translating functional molecular knowledge into crop-breeding success.

Nature reviews. Genetics·2026
Same journal

Computational approaches for multimodal lineage tracing.

Nature reviews. Genetics·2026
Same journal

Time matters: circadian genetics and the molecular logic of human health and disease.

Nature reviews. Genetics·2026
See all related articles

RNA interference (RNAi) regulates gene expression by targeting messenger RNAs for degradation. Emerging research shows RNAi also controls genome-level processes like epigenetic modifications and DNA elimination for targeted gene silencing.

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • RNA interference (RNAi) is a conserved biological process utilizing small antisense RNAs to degrade target messenger RNAs (mRNAs).
  • Recent studies indicate RNAi pathways extend beyond mRNA targeting to influence genome regulation.
  • These broader roles involve epigenetic modifications and DNA processing.

Purpose of the Study:

  • To explore the genome-level regulatory functions of RNA interference (RNAi).
  • To understand how RNAi machinery directs epigenetic alterations and gene silencing.
  • To investigate the role of RNAi in DNA elimination and meiotic silencing.

Main Methods:

  • Analysis of existing literature on RNAi pathways.
  • Review of studies detailing epigenetic modifications induced by dsRNA.

Related Experiment Videos

  • Examination of research on RNAi's role in DNA elimination and meiosis.

    • Main Results:

    • RNAi machinery, including dsRNA and associated proteins, can induce epigenetic alterations at homologous DNA sequences.
    • These alterations lead to transcriptional gene silencing and, in some cases, DNA elimination.
    • RNAi also functions in silencing unpaired DNA regions during meiosis in certain organisms.

    Conclusions:

    • RNA interference (RNAi) plays a significant role in genome regulation beyond mRNA degradation.
    • RNAi mechanisms facilitate targeted epigenetic modifications and gene silencing.
    • These processes are crucial for controlling specific genomic regions and cellular functions.