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Pediatric mitochondrial disease: do we have the energy to make the diagnosis?

Joe C Rutledge1, Laura S Finn

  • 1Department of Laboratory Medicine, University of Washington School of Medicine and Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA. joe.rutledge@seattlechildrens.org

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|January 5, 2005
PubMed
Abstract

No abstract available in PubMed .

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Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...

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