Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The telomerase cycle: normal and pathological aspects.

Michele Brunori1, Pierre Luciano, Eric Gilson

  • 1Laboratoire de Biologie Moleculaire de la Cellule, l'Ecole Normale de Lyon, CNRS UMR5161, INRA U1237, IFR12846 Allée d'Italie, 69364 Lyon cedex 07, France.

Journal of Molecular Medicine (Berlin, Germany)
|January 5, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rap1-mediated steric hindrance protects telomeres from MRX sensing.

Nature structural & molecular biology·2026
Same author

SIRT3 deSUMOylation sustains hematopoietic stem cell activities under stressful conditions via the DHX58-IRF7 axis.

Haematologica·2026
Same author

Characteristics and safety outcomes of rheumatoid arthritis patients treated with AMGEVITA<sup>®</sup> in the United Kingdom using data from a national register.

Arthritis research & therapy·2026
Same author

The adaptive molecular landscape of reprogrammed telomeric sequences.

Nature communications·2026
Same author

Molecular evolution of animal aging.

The EMBO journal·2026
Same author

TRF2 Upregulates Protein Phosphatase 2A Subunit PPP2R2C to Attenuate DNA Damage Response at Telomeres and Pericentromeres Upon Replicative Stress.

Aging and disease·2026
Same journal

Integrative genetic and functional analysis of autosomal dominant hearing loss in 108 multigenerational families.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapy.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Zinc-binding protein metallothionein 3 protects vascular smooth muscle cells from ferroptosis via blocking lysosomal degradation of GPX4.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Clinical utility of cerebrospinal fluid interleukin-10 in central nervous system lymphoma: a molecular neuropathology-informed diagnostic meta-analysis.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Molecular regulation of PGC-1α: from protein-protein interactions and post-translational modifications to pharmacological modulation.

Journal of molecular medicine (Berlin, Germany)·2026
Same journal

Molecular determinants of thromboinflammatory activation in inflammatory bowel disease.

Journal of molecular medicine (Berlin, Germany)·2026
See all related articles

Telomeres protect chromosome ends, and their length is regulated by telomerase. This review examines telomere dynamics during the cell cycle and stress, impacting normal and cancer cells.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Telomeres are protective nucleoprotein complexes at eukaryotic chromosome ends, crucial for stability.
  • Telomerase, a reverse transcriptase, maintains telomere length in specific cell types, including cancer cells.
  • Telomere shortening triggers cell cycle arrest in the absence of telomerase activity.

Purpose of the Study:

  • To review the dynamic organization and remodeling of telomeres during the cell cycle and stress response.
  • To compare telomere dynamics in yeast and human cells.
  • To discuss the cellular consequences of telomere modifications in normal and cancer cells.

Main Methods:

  • Literature review of recent data on telomere organization and remodeling.
  • Comparative analysis of telomere dynamics in yeast and human systems.

Related Experiment Videos

  • Examination of cellular consequences and roles in cancer initiation and progression.

    • Main Results:

    • Telomeres undergo dynamic reorganization and remodeling throughout the cell cycle and in response to stress.
    • Conservation and differences in telomere dynamics exist between yeast and human cells.
    • Telomere modifications have significant cellular consequences, influencing both normal cell function and cancer development.

    Conclusions:

    • Telomere and telomerase activity are tightly regulated, influencing cell fate.
    • Understanding telomere dynamics is critical for comprehending cancer initiation and progression.
    • Telomeres play complex, seemingly contradictory roles in cancer biology.