Related Experiment Video
Updated: Aug 17, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
ApoE: crossroads between Alzheimer's disease and atherosclerosis
Tatjana Stojakovic1, Hubert Scharnagl, Winfried März
1Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, A-8036 Graz, Austria.
Abstract:
Apolipoprotein E (apoE) is a major constituent of lipoproteins in the plasma and in the brain. There are three common apoE isoforms, termed E2, E3, and E4. By virtue of its ability to bind to lipoprotein receptors, apoE plays a key role in the metabolism of triglyceride-rich lipoproteins in the plasma. Homozygous carriers of apoE2 have an increased risk to develop type III hyperlipoproteinemia, whereas apoE4 is associated with elevated levels of low-density lipoprotein cholesterol. In the brain, apoE is associated with cholesterol-rich lipoproteins and is involved in the transport of cholesterol to neurons. The genetic polymorphism of apoE is among the strongest determinants of the risk and mean age of onset of Alzheimer's disease. The mechanism by which apoE isoforms differentially contribute to disease expression is not known.
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Atherosclerosis I: Introduction
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction

