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Related Experiment Videos

Kidney function estimated with different formulas in centenarians.

K Wieczorowska-Tobis1, Z I Niemir, P Guzik

  • 1Laboratory for Gerontology and Geriatrics, Department of Pathophysiology, University of Medical Sciences, Poznań, Poland. kwt@tobis.pl

Roczniki Akademii Medycznej W Bialymstoku (1995)
|January 6, 2005
PubMed
Summary

Kidney function estimation in centenarians varied significantly between Cockcroft-Gault (CG), Baracskay (B), and Modification of Diet in Renal Diseases (MDRD) formulas. Further research is needed to determine the most reliable formula for the elderly.

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Area of Science:

  • Gerontology
  • Nephrology
  • Biostatistics

Background:

  • Estimating kidney function (KF) in the elderly is crucial for accurate medical management.
  • The accuracy of the Cockcroft-Gault (CG) formula for creatinine clearance is increasingly questioned in older populations.
  • Newer equations, including the Modification of Diet in Renal Diseases (MDRD) and a specialized formula by Baracskay (B), have been proposed.

Purpose of the Study:

  • To compare the kidney function (KF) estimations derived from the CG, B, and MDRD formulas in centenarians.
  • To assess the reliability of these formulas in a very elderly population.

Main Methods:

  • The study included 50 centenarians (100-111 years old).
  • Kidney function was calculated using the CG, B, and MDRD formulas.

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  • Statistical analysis was performed to compare results between formulas and by gender.

    • Main Results:

    • The CG formula yielded lower KF estimations compared to B and MDRD formulas across the entire cohort and in females.
    • In males, CG and B results were similar, but MDRD results were significantly higher than both CG and B.
    • Gender did not impact results for CG and MDRD, but the B formula showed higher mean values in females.

    Conclusions:

    • Significant discrepancies exist in kidney function estimations among CG, B, and MDRD formulas in centenarians.
    • Further studies incorporating a reference standard are required to identify the most accurate formula for KF calculation in the elderly.