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Updated: Jul 27, 2026
Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Is a hypothermic effect of LY300164, valproate and phenobarbital evident in mice?
M J Swiader1, J J Luszczki, A Zwolan
1Department of Pharmacology and Toxicology, Medical University of Lublin, Poland. mswiader@hipokrates.am.lublin.pl
Purpose:
The aim of this study was to evaluate the influence of LY300164 (an AMPA/kainate receptor antagonist) administered alone or in combination with valproate (VPA) or phenobarbital (PB) on body temperature in mice.
Material And Methods:
The temperature measurements were performed in Albino Swiss mice injected with the respective drugs by using a rectal thermistor thermometer.
Results:
LY300164, at the dose of 2 mg/kg, did not affect the body temperature of the examined animals. However, the combination of LY300164 (2 mg/kg) with VPA (165 mg/kg) resulted in a significant decrease in body temperature within 60-180 min after their peak of maximum anticonvulsant activity. Moreover, VPA (269 mg/kg) administered alone, evidently produced hypothermic effects at the times between 120-180 min after the peak of the maximum antiseizure effect. In contrast, phenobarbital administered alone or in combination with LY300164 did not affect the body temperature in the mice.
Conclusions:
Hypothermia induced by LY 300164 combined with VPA may be useful in various central nervous system disease treatments.
