[The immuno-deficient mice transplantion models in study of human hematopoietic stem cells--review]

A variety of immuno-deficient animal models has been used in the detection of human hematopoietic stem/progenitor cells and up to date make many remarkable contribution to the study of detectron cell biology. An ideal immuno-deficient animal should not only have complete immune defects, be able to transplant human hematopoietic stem/progenitor cells with high efficacy, but also survive long enough for observation. In this review, the development of immuno-deficient mice from nude, SCID, to NOD/SCID etc is introduced and much attention is put on the features, priority and shortcomings of those key animal models and their application in HSC research. The progress, the future directions and prospects of these immuno-deficient mice models are stressed.