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[Human serum alcaline phosphatase and ageing]
M R Negrão1, M J Martins, E Ramos
1Serviço de Bioquimica (U-38 FCT), Faculdade de Medicina, Universidade do Porto, Porto.
Acta Medica Portuguesa
|January 6, 2005
Summary
Serum alkaline phosphatase activity increases with age in humans, acting as a potential biomarker for aging. This finding mirrors observations in experimental aging models.
Area of Science:
- Biochemistry
- Gerontology
- Clinical Chemistry
Context:
- Experimental aging models show an inverse relationship between age and alkaline phosphatase activity.
- Understanding human aging biomarkers is crucial for health research.
Purpose:
- To characterize serum alkaline phosphatase activity in humans based on age and gender.
- Investigate the correlation between alkaline phosphatase levels and aging in a human population.
Summary:
- Serum alkaline phosphatase was measured in 203 adults aged 40+.
- In men, activity increased from the 5th to 6th decade, then stabilized. In women, it rose slightly and then increased after age 69.
- A significant positive correlation was found between serum alkaline phosphatase and age across all participants.
Impact:
- Serum alkaline phosphatase activity can serve as a biomarker for human aging.
- Findings align with previous observations in experimental animal models.
- Provides insights into age-related physiological changes.