Clinical predictors of sleep disordered breathing in children at moderate altitude
Juan Carlos Vázquez1, Francisco Marentes Montes, Carlos Aboitiz Rivera
1Departamento de Fisiología Respiratoria y Laboratorio de Sueño, Instituto Nacional de Enfermedades Respiratorias (INER), Secretaría de Salud (SSA), Mexico City, Mexico. jcvaz@mexis.com
Insights
Validated clinical indicators for childhood sleep disordered breathing (SDB) are limited, especially at moderate altitudes. This study identified key predictors like age, obesity, and enlarged tonsils in children with SDB.
Area of Science:
- Pediatric Sleep Medicine
- Respiratory Physiology
- Clinical Diagnostics
Background:
- Validated clinical indicators for childhood sleep disordered breathing (SDB) are scarce.
- Moderate altitude environments may increase hypoxemic complications, making oximetry evaluation efficient.
Purpose of the Study:
- To identify clinical predictors of SDB in children evaluated at moderate altitude.
- To assess the utility of pulse oximetry in diagnosing SDB in this population.
Main Methods:
- 158 children with suspected sleep apnea in Mexico City (2240 m) underwent clinical evaluation.
- Nocturnal monitoring included pulse oximetry, snoring, and body position tracking.
Main Results:
- 84% of children had >5 desaturations/hour; 63% had >10; 34% had >20.
- Predictors for >10 desaturations included age ≤5 years, obesity, enlarged tonsils, and male gender.
- Witnessed apneas, age ≤5 years, obesity, and enlarged adenoids/tonsils predicted >20 desaturations.
Conclusions:
- Age, gender, witnessed apneas, enlarged tonsils/adenoids, and obesity are clinical predictors of SDB in children at moderate altitude.
- These findings aid in identifying children needing further sleep evaluation.
Background:
Validated clinical indicators of sleep disordered breathing (SDB) in children are scarce and none generated at moderate altitude where hypoxemic complications could be frequent and oximetry evaluation might be very efficient.
Methods:
A total of 158 children consecutively referred to a sleep clinic in Mexico City (2240 m) for suspected sleep apnea underwent clinical evaluation and nocturnal monitoring of pulse oximetry, snoring and body position.
Results:
Mean age was 4.9 years (SD 2.5) and 68.4% were males. A total of 84% of children were found with more than five desaturations per hour (>/=4%) while 63% and 34% had more than 10 and 20 desaturations, respectively. Based on logistic regression models, age =5 was the only predictor for more than five desaturations per hour (OR 4.5, 95% CI 1.6-12.6). Clinical predictors of more than 10 desaturations were age =5 years (OR 4.0, 95% CI 1.9-8.8), obesity (OR 3.5, 95% CI 1.3-9.1), enlarged tonsils (OR 3.5, 95% CI 1.6-8.1) and male gender (OR 2.4, 95% CI 1.1-5.2). Witnessed apneas (OR 3.1, 95% CI 1.7-7.0), age =5 years (OR 2.6; 95% CI 1.2-5.5), obesity (OR 2.4, 95% CI 1.0-5.6) and simultaneous enlargement of adenoids and tonsils predicted more than 20 desaturations (OR 2.4; 95% CI 1.0-5.8).
Conclusions:
Age, gender, witnessed apneas, enlarged tonsils or adenoids and obesity were clinical predictors of SDB in children referred to a sleep clinic at moderate altitude.
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