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Diabetic neuropathic cachexia associated with malabsorption.

D F D'Costa1, D E Price, A C Burden

  • 1Leicester General Hospital, UK.

Diabetic Medicine : a Journal of the British Diabetic Association
|March 1, 1992
PubMed
Summary
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Diabetic neuropathic cachexia, marked by pain and weight loss, was linked to malabsorption in four patients. Treatment with pancreatic supplements and high-calorie diets led to significant recovery, suggesting pancreatic dysfunction as a cause.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Neurology

Background:

  • Diabetic neuropathic cachexia presents with neuropathic pain and severe weight loss of unknown origin.
  • This condition affects diabetic patients, leading to significant anorexia and depression.

Observation:

  • Four diabetic patients presented with neuropathic pain, anorexia, depression, and substantial weight loss (median 16 kg).
  • Diagnostic tests revealed impaired fat absorption (low butterfat test, low serum and delayed urinary xylose) but normal small bowel histology and other organ function tests.

Findings:

  • Malabsorption was identified as a key issue in these patients with diabetic neuropathic cachexia.
  • The malabsorption may stem from pancreatic dysfunction, as suggested by the clinical presentation and response to treatment.

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Implications:

  • The findings suggest that malabsorption, potentially due to pancreatic dysfunction, is a significant factor in diabetic neuropathic cachexia.
  • Investigating and treating malabsorption should be a crucial part of managing diabetic neuropathic cachexia, potentially improving patient outcomes.